High urine volume and low urine osmolality are risk factors for faster progression of renal disease

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High urine volume and low urine osmolality are risk factors for faster progression of renal disease.

BACKGROUND Increased fluid intake slows renal disease progression in animal models. The relevance of these findings to human renal disease is not clear, although increased fluid intake often is recommended to patients with chronic renal insufficiency. This study tested the hypothesis that urine volume, urine osmolality (Uosm), or both are significantly associated with glomerular filtration rate...

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Severe hyponatremia with high urine sodium and osmolality.

A 49-year-old woman (previous history of childhood asthma, no medication) presented to the emergency department with nausea and vomiting that had occurred for 5 days and slurred speech for 1 day prior to presentation. The patient denied use of alcohol and illicit drugs. Physical examination revealed her blood pressure to be 125/70 mmHg; she had no postural drop and had a regular pulse of 72 bea...

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Interpretation of Urine Electrolytes and Osmolality

A. S. Reddi, Fluid, Electrolyte and Acid-Base Disorders, DOI 10.1007/978-1-4614-9083-8_2, © Springer Science+Business Media New York 2014 Measurement of urine Na + , Cl − , and K + is rather common in hospitalized patients, and these urine electrolytes are useful in the diagnostic evaluation of volume status, hyponatremia , acute kidney injury (AKI) , metabolic alkalosis, hypokalemia and urine ...

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DDAVP and urine osmolality in refractory enuresis.

A double blind crossover trial of 20 micrograms intranasal 1-deamino-8-d-arginine vasopressin (DDAVP) versus placebo was carried out in 17 children with intractable enuresis aged between 6 and 13 years who had failed to respond to drugs and an enuresis alarm. Fluid intake was not restricted. There was a significant reduction in the number of wet nights. Seven children (41%) were cured or showed...

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Urine Proteomics and Biomarkers in Renal Disease

The application of urine proteomics is a useful approach to the study of the proteins involved in healthy and diseased kidneys and may provide a noninvasive approach to assess disease activity and to monitor clinical response in patients with renal diseases. This technique may provide an additional tool in clinical trials and for the assessment of prognosis for patients. Both soluble proteins a...

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ژورنال

عنوان ژورنال: American Journal of Kidney Diseases

سال: 2003

ISSN: 0272-6386

DOI: 10.1016/s0272-6386(03)00193-8